Michael Smallegan

michae_smalleganAssociate Programmer Analyst

Education

B.S., Physics and Complex Systems, University of Michigan, Ann Arbor, Michigan

Research Description

Michael’s work aims to bridge computational/ theoretical science and wet lab science. His current research focus is on integrating datasets from multiple investigative approaches: proteomics, metabolomics, genomics, etc. to understand the mechanisms and biological function of reversible protein modifications involved in modulating signal transduction, chromatin dynamics and metabolism.

 Selected Publications

* Denotes co-first author

  • Baeza J.*, Smallegan M.J.*, Denu J.M. (2015) Site-specific reactivity of nonenzymatic lysine acetylation. ACS Chemical Biology. 10(1):122-128
  • Baeza J., Dowell J.A., Smallegan M.J., Fan J., Amador-Noguez D., Khan Z., Denu J.M. (2014) Stoichiometry of site-specific lysine acetylation in an entire proteome. J. Biol. Chem. 289(31), 21326-21338 [Featured as a JBC Paper of the Week.]

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