Linking metabolism and epigenetics

Chromatin remodeling enzymes rely on co-enzymes derived from metabolic pathways, suggesting coordination between nuclear events and metabolic networks. Investigations are underway to understand the link between metabolism and the regulation of epigenetic mechanisms. We hypothesize that certain chromatin modifying complexes have evolved to exquisitely ‘sense’ metabolite levels and respond accordingly, modifying specific chromatin loci for altered gene expression. To test these hypotheses we are using mass spectrometry to monitor post translational modifications and metabolomics.

method
Proteomics workflow to quantitate histone post-translational modifications.

HistoneProteomicsHeatmaps

 

 

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