Vyacheslav (Slava) Kuznetsov, PhD

Selected Publications

H2A. Z deposition by the SWR complex is stimulated by polyadenine DNA sequences in nucleosomes. Cynthia Converso, Leonidas Pierrakeas, Lirong Chan, Shalvi Chowdhury, Emily de Onis, Vyacheslav I Kuznetsov, John M Denu, Ed Luk. PLoS biology. 2025.

Intrinsic catalytic properties of histone H3 lysine-9 methyltransferases preserve monomethylation levels under low S-adenosylmethionine. Spencer A. Haws*, Lillian J. Miller*, Diego Rojas La Luz, Vyacheslav I. Kuznetsov, Raymond C. Trievel, Gheorghe Craciun, and John M. Denu. JBC 2023.

Potent Activation of NAD ⁺-Dependent Deacetylase Sirt7 by Nucleosome Binding. Kuznetsov VI, Liu WH, Klein MA, and Denu JM. ACS Chem Biol. 2022.

Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6. Liu WH, Zheng J, Feldman JL, Klein MA, Kuznetsov VI, Peterson CL, Griffin PR, Denu JM.  Nat Commun 2020.

Mechanism of Activation for the Sirtuin 6 Protein Deacylase. Klein MA, Lie C, Kuznetsov VI, Feltenberger JB, Tang W, Denu JM. J Biol Chem 2020.

General method for rapid purification of native chromatin fragments. Kuznetsov VI, Haws SH, Fox CA, Denu JM. J Biol Chem 2018.