Publications

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2022

Increased expression of SLC25A1/CIC causes an autistic-like phenotype with altered neuron morphology. Rigby MJ, Orefice NS, Lawton AJ, Ma M, Shapiro SL, Yi SY, Dieterich IA, Frelka A, Miles HN, Pearce RA, Yu JPJ, Li L, Denu JM, Puglielli L. Brain 2022.

Discovery and Mechanism of Small Molecule Inhibitors Selective for the Chromatin-Binding Domains of Oncogenic UHRF1. Liu WH, Miner RE, Albaugh BN, Ananiev GE, Wildman SA, Denu JM. Biochemistry 2022.

Sirt6 regulates lifespan in Drosophila melanogaster. Taylor JR, Wood JG, Mizerak E, Hinthorn S, Liu J, Finn M, Gordon S, Zingas L, Chang C, Klein MA, Denu JM, Gorbunova V, Seluanov A, Boeke JD, Sedivy JM, Helfand SL. PNAS 2022.

Metabolomic Analysis of Carbohydrate and Amino Acid Changes Induced by Hypoxia in Naked Mole-Rat Brain and Liver. Cheng H, Qin YA, Dhillon R, Dowell JDenu JM, Pamenter ME. Metabolites 2022.

SLC13A5/NaCT overexpression causes disrupted white matter integrity and an autistic-like phenotype. Rigby MJ, Orefice NS, Lawton AJ, Ma M, Shapiro SL, Yi WY, Dieterich IA, Frelka A, Miles HN, Pearce RA, Yu JPJ, Denu JM, Puglielli L. Brain Communications 2022.

2021

Short-chain fatty acids activate acetyltransferase p300. Thomas SP and Denu JMeLife 2021.

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice. Pak HH, Haws SA, Green CL, Koller M, Lavarias MT, Richardson NE, Yang SE, Dumas SN, Sonsalla M, Bray L, Johnson M, Barnes S, Darley-Usmar V, Zhang J, Yen CE, Denu JM, Lamming DW. Nat Metab. 2021.

Gut microbiome variation modulates the effects of dietary fiber on host metabolism. Murga-Garrido SM, Hong Q, Cross TL, Hutchison ER, Han J, Thomas SP, Vivas EI, Denu JM, Ceschin DG, Tang ZZ, Rey FE. Microbiome 2021.

Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism. Rigby MJ, Lawton AJ, Kaur G, Banduseela VC, Kamm WE, Lakkaraju A, Denu JM, Puglielli L. Commun Biol. 2021.

Benchmarking Quantitative Performance in Label-Free Proteomics. Dowell JA, Wright LJ, Armstrong EA and Denu JM. ACS Omega 2021.

Catalysis by protein acetyltransferase Gcn5. Albaugh BN and Denu JMBiochim Biophys Acta Gene Regul Mech. 2021.

2020

Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6. Liu WH, Zheng J, Feldman JL, Klein MA, Kuznetsov VI, Peterson CL, Griffin PR, Denu JM.  Nat Commun 2020.

Mechanism of Activation for the Sirtuin 6 Protein Deacylase. Klein MA, Lie C, Kuznetsov VI, Feltenberger JB, Tang W, Denu JM. J Biol Chem 2020.

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence. Haws SA, Yu D, Ye C, Wille CK, Nguyen LC, Krautkramer KA, Tomasiewicz JL, Yang SE, Miller BR, Liu WH, Igarashi K, Sridharan R, Tu BP, Cryns VL, Lamming DW, Denu JMMol Cell 2020.

Revealing Dynamic Protein Acetylation across Subcellular Compartments. Baeza J, Lawton AJ, Fan J, Smallegan MJ, Lienert I, Gandhi T, Bernhardt OM, Reiter L, Denu JM. J Proteome Res 2020.

Metabolism and the Epigenome: A Dynamic Relationship. Haws SA, Leech CM and Denu JMTrends Biochem Sci. 2020.

Biological and Catalytic Functions of Sirtuin 6 as Targets for Small-Molecule Modulators. Klein MA and Denu JM. J Biol Chem. 2020.

2019

A practical guide for analysis of histone post-translational modification by mass spectrometry: Best practices and pitfalls. Thomas SP, Haws SA, Borth LE and Denu JM. Methods 2019.

Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk. Dieterich IA, Lawton AJ, Peng Y, Yu Q, Rhoads, TW, Overmyer, KA, Cui Y, Armstrong EA,  Howell PR, Burhans MS, Li L, Denu JM, Anderson RM, Puglielli L. Nat Commun 2019.

Site-Specific Lysine Acetylation Stoichiometry Across Subcellular Compartments. Lindahl AJ, Lawton AJ, Baeza J, Dowell JA and Denu JM. Methods Mol Biol. 2019.

PGC-1a Integrates a Metabolism and Growth Network Linked to Caloric Restriction. Miller KN, Clark JP, Martin SA, Howell PR, Burhans MS, Haws SA, Johnson NB, Rhoads TW, Pavelec DM, Eliceiri KW, Roopra AS, Ntambi JM, Denu JM, Parks BW, Anderson RM. Aging Cell 2019.

Histone Acetyltransferase 1 Links Metabolism and Transcription to Cell-Cycle Progression. Denu JM. Mol Cell 2019.

2018

General method for rapid purification of native chromatin fragments. Kuznetsov VI, Haws SH, Fox CA, Denu JM. J Biol Chem 2018.

An Inactivating Mutation in the Histone Deacetylase SIRT6 Causes Human Perinatal Lethality. Ferrer CM, Alders M, Postma AV, Park S, Klein MA, Cetinbas M, Pajkrt E, Glas A, van Koningsbruggen S, Christoffels VM, Mannens MMAM, Knegt L, Etchegaray JP, Sadreyev RI, Denu JM, Mostoslavsky G, van Maarle MC, Mostoslavsky R. Genes Dev. 2018.

Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. Latorre-Muro P, Baeza J, Armstrong EA, Hurtado-Guerrero R, Corzana F, Wu LE, Sinclair DA, López-Buesa P, Carrodeguas JA, Denu JMMol Cell 2018.

2017

Identifying Dysregulated Epigenetic Enzyme Activity in Castrate-Resistant Prostate Cancer Development. Lee JH, Yang B, Lindahl AJ, Damaschke N, Boersma MD, Huang W, Corey E, Jarrard DF, Denu JMACS Chem Biol. 2017.

Chemical Signaling Between Git Microbiota and Host Chromatin: What is You Gut Really Saying? Krautkramer KA, Rey FE, Denu JM. J Biol Chem 2017.

Metabolic Programming of the Epigenome: Host and Git Microbial Metabolite Interactions with Host Chromatin. Krautkramer KA, Dhillon RS, Denu JM, Carey HV. Transl Res. 2017.