at the Wisconsin Institute for Discovery

Lab News


  • April 2021 – John is selected as an inaugural Fellow of the American Society for Biochemistry and Molecular Biology (ASBMB)! Congrats John!!
  • April 2021 – Spencer successfully defends his thesis work on the effects of methionine restriction on histone modifications! Great job Spencer!! Best of luck in your post-doctoral work in the Cremin Lab at the University of Pennsylvania!
  • March 2021 – Cassie is awarded an NSF Graduate Research Fellowship!
  • February 2021 – Sara Slager joins the lab as an undergraduate research assistant! Welcome Sara!
  • January 2021 – Cassie is accepted into the Metabolism and Nutrition Training Grant (MANTP)
  • January 2021 – Julie Bolding joins the lab as a visiting PhD student from the University of Copenhagen for the next 6 months to expand her work on sirtuins. Welcome Julie!!


  • December 2020 – Morgan graduates from UW-Madison with a B.S. in Biology. Now she’s off to earn her M.D. from the University of Wisconsin-Madison School of Medicine and Public Health, good luck Morgan!!
  • November 2020 – Lily passes her preliminary exam, congrats Lily!
  • October 2020 – Mark successfully defends his doctoral thesis and is off to start a post-doctoral position at Promega in Madison!! Congrats and best of luck Mark, stay in touch!
  • June 2020 – Robert and Logan leave the lab to begin the next stages of their careers, best of luck guys! We will miss you both
  • June 2020 – Mark’s review on small-molecule modulators for Sirt6 is published in JBC! Way to go Mark!
  • May 2020 – A joint effort from Spencer, Cassie and John results in the publication of a review article on epigenetic and metabolism in Trends in Biochemical Sciences, congrats guys!
  • March 2020 – Following guidelines from UW, lab members make the switch from bench work to working from home to prevent the spread of COVID-19. Please stay safe everyone
  • April 2020 – Jessica is awarded the NIH funded Big Data 2 Knowledge Training Fellowship, congrats!
  • April 2020 – Spencer’s research on an adaptive epigenetic mechanism following methionine depletion is published in Molecular Cell, great job Spencer!
  • February 2020 – Bianca Chavez joins the lab! Welcome onboard!
  • January 2020 –  Mark’s research on SIRT6 activation is published in JBC and is highlighted as an Editor’s Pick, way to go Mark
  • January 2020 – Jessica Han joins the lab! Welcome Jessica!
  • January 2020 – Prof. Rick Eisenstein joins the lab for a sabbatical to work on iron metabolism, welcome Rick!


  • December 2019 – Cassie Leech and Jose Moran join the lab! Welcome guys!
  • September 2019 – Sherry Bakhtiar joins the lab as a Senior Research Specialist! Welcome Sherry!
  • August 2019 – Ana successfully defends her thesis! Way to go Ana!
  • May 2019 – Mitchell leaves the lab to begin pursuing missionary work, best of luck!!
  • January 2019 – Robert Miner and Logan Wright join the lab! Welcome!


  • December 2018 – Lily Miller and Mitchell Carlson join the lab, welcome to the jungle!
  • December 2018 – Sydney rolls out the Epigenetics Hub to the public at the Illuminating Connections, you can check out the videos here!
  • October 2018 – Laura gives a talk at the UW Department of Neurologic Surgery Research Day!
  • October 2018 – Amy and Ana give Science on the Square talks for the Wisconsin Science Festival.
  • September 2018 – Pedro Lattore’s work describing the dynamic acetylation of PCSK1 comes to fruition and is published in Molecular Cell. Cheers Pedro, hope all is well back in Spain!
  • September 2018 – Sydney and Spencer present posters at the Morgridge Frontiers in Metabolism Conference.
  • August 2018 –  Alexis, Amy, Ana, Slava, and Spencer attend the North American Mass Spectrometry Summer School.
  • August 2018 – Slava’s method of purifying native chromatin from yeast is published in JBC!
  • August 2018 – Ana gives a talk at the Wisconsin Human Proteomics Symposium.
  • June 2018 – Spencer gives a talk at the FASEB Biological Methylation Conference in Florence, Italy!
  • May 2018 – Spencer is awarded the Markey Foundation travel grant, have fun in Italy!
  • April 2018 – Spencer gives a talk at the Morgridge Institute and UW-Madison Metabolism Symposium.
  • April 2018 – Mark leaves to start his summer R&D research internship at Promega, go get em’!
  • March 2018 – James receives pilot funding from the Wisconsin Alzheimer’s Disease Research Center (ADRC) to determine the importance of histone depletion in driving human AD-associated transcriptional dysfunction
  • March 2018 – Collaborative work with the Mostoslavsky Lab detailing a devastating SIRT6 mutation is published in Genes Dev. Way to help Mark!
  • February 2018 – Mark is awarded The Ride Scholarship from the Carbone Cancer Center!


  • November 2017 –  Jin’s work using microarrays to measure HAT/HDAC activities is published in ACS Chem Bio.!
  • November 2017 – Laura Borth join the group, welcome on board!
  • November 2017 – Rush publishes review on using comparative physiology to understand the aging mitochondria.
  • November 2017 – Kim’s review about how the gut microbiome influences host epigenome is published in Translational Research!
  • September 2017 – Ana wins a poster award at the IPiB Retreat, way to go Ana!
  • May 2017 – Wallace Liu accepted on the Molecular and Applied Nutrition Training Program (MANTP)!
  • May 2017 – Julie Thelen graduates from UW-Madison with a BS in Biochemistry. Congratulations Julie!
  • April 2017 – The Denu Lab takes a trip to American Society for Biochemistry and Molecular Biology (ASBMB) conference in Chicago. Both Rush Dhillon and Spencer Haws will be giving talks. McCormick place here we come!
  • April 2017 – Beatriz Camacho passes her preliminary exam! Congrats Beatriz!
  • April 2017 – Dr. Jin-Hee Lee finishes her post-doc and begins work at Pharmaceutical Product Development (PPD) in Madison!
  • March 2017 – Kimberly Krautkramer successfully defends her doctoral thesis and is now working to complete her M.D. degree! Keep up the work!
  • March 2017 – Sydney Thomas is awarded an NSF Graduate Research Fellowship. Way to Go!
  • Jan 2017 – Josh Baeza successfully defends his doctoral thesis! On to a post-doc at UPenn! Congrats Josh, we’ll do our best to keep all your plants alive!
  • Jan 2017 – Steven Bieser joins the lab! Welcome Steven!
  • Jan 2017 – Spencer Haws accepted on the Molecular and Applied Nutrition Training Program (MANTP)!


  • Dec 2016 – Alexis Lawton, Sydney Thomas, and Yiming Qin join the group! Welcome on board!
  • Dec 2016 – Rush Dhillon’s review on using comparative physiology to study the effect of aging on the mitochondria is published in Molecular and Cellular Endocrinology. (check out his hand drawn figures!)
  • Dec 2016 – Kimberly Krautkramer‘s work linking gut microbiota to host epigenetics is published in Molecular Cell. Congratulations!
  • Nov 2016 – Zhangli Su‘s work on KDM4 reader domain specificity is published in Nature Communications! Nice work!
  • Oct 2016 – Wallace Liu joins the lab. Welcome Wallace!
  • Sept 2016 – Michael Smallegan departs the Denu lab to travel the world for a year before starting graduate studies at UC Boulder. Have a great trip!
  • Aug 2016 – Jing Fan begins her one year fellowship in the metabolism theme at the Morgridge Institute for Research before becoming a Morgridge investigator and assistant professor in the University of Wisconsin-Madison Department of Nutritional Sciences. Congratulations!!!!!
  • July 2016 – Jing Fan and Josh Baeza’s work is published in Methods in Enzymology. Congratulations!
  • June 2016 – Zhangli Su heads off to to start her Postdoc in Anindya Dutta’s Lab at University of Virginia Medical School. Congratulations and good luck!!
  • May 2016 – John is awarded Vilas Faculty Mid-Career Investigator Award.
  • May 2016 – Nicole Rademacher graduates with a BS in Microbiology and joins the Shelef Lab in the UW Department of Medicine as a research assistant! Congratulations and best luck!
  • May 2016 – Keighley Reisenaur graduates with a BS in Genetics and a second degree in Spanish and starts graduate school at Baylor in the Department of Biology! Congratulations and best luck!
  • May 2016 – Ben Baeten graduates with a BS in Computer Sciences! Congratulations!
  • April 2016 – Kim Krautkramer speaks at the Keystone Symposium for Gut Microbiota, Metabolic Disorders, and Beyond.
  • March 2016 – Zhangli Su successfully defended her doctoral thesis. Congratulations Dr. Su (aka Dr. Ninja Kitty)!
  • March 2016 – Rush Dhillon awarded R03 grant for Comparative Physiological Studies of Aging.
  • March 2016 – Pedro Lattore joins us from Zaragoza, Spain, for a 6-month study abroad fellowship.
  • John receives 2016 University of Wisconsin Kellett Mid-Career Award from WARF. Congratulations John for winning this award!
  • Feb 2016 – Review article on combinatorial histone modifications (Zhangli Su) is published in ACS Chemical Biology. Review article on protein acetylation in mitochondria (Josh Baeza and Michael Smallegan) is published in Trends in Biochemical Sciences. Congrats Zhangli, Josh and Michael!!
  • Jan 2016 – Mark Klein accepted to the Chemistry-Biology Interface Training Program.



  • December 2014 – Josh and Shuiming win the BMC Holiday Party Ping Pong Tournament! Congrats! Way to take home the victory for the lab.
  • December 2014 – Mark Klein (IPiB) joins the lab. Welcome Mark!
  • December 2014 – Jessica Feldman successfully defended her doctoral thesis. Congratulations Dr. Feldman!!
  • October 2014 – The Denu Lab spent the day hiking up at Devil’s Lake. Check out the lab images page for pictures from the day.
  • October 2014 – Zach Kemmerer and Mark Klein (IPiB) join the lab for rotations.
  • August 2014 –  Kristin Dittenhafer-Reed heads off to start her Postdoc in Jeff MacKeigan’s lab at the Van Andel Research Institute. Congratulations and good luck Kristin!
  • August 2014 – We are currently accepting rotation students for Fall 2014. Please check the opportunities page.
  • August 2014 – Kristin Dittenhafer-Reed successfully defended her doctoral thesis. Congratulations Dr. Dittenhafer-Reed!!
  • August 2014 – The work by Josh Baeza is chosen as a paper of the week in the JBC. Congratulations Josh!
  • June 2014 – It is with great sadness that we report the passing of our dear pet and lab mate, Tuffy Jr. His presence will certainly be missed, but he will not be forgotten.
  • June 2014 – Josh Baeza’s work is published in the Journal of Biological Chemistry. Congratulations Josh!
  • 2014 MCEM (Midwest Chromatin and Epigenetics Meeting) will be held in WID from May 18 to May 20.
  • April 2014 – Zhangli Su’s work is published in Epigenetics and Chromatin. Congratulations Zhangli!
  • March 2014 – Rush Dhillon joins the lab. Welcome Rush!
  • March 2014 – John is featured in ASBMB Today.
  • February 2014 – Jing Fan joins the lab. Welcome Jing!
  • February 2014 – Wei Yu heads off to Fudan University in Shanghai, China to start his career as a professor. Congratulations and good luck Wei!
  • January 2014 – Viacheslav Kuzniestsov joins the lab. Welcome Slava!