Spencer Haws

Credentials: Postdoctoral Scholar

Email: shaws@wisc.edu

330 North Orchard Street
Madison, Wisconsin 53715


Ph.D., Molecular and Biochemical Nutrition, University of Wisconsin-Madison

B.S., Nutritional Sciences, University of Wisconsin-Madison

Research Description

Interrogating the metabolism-epigenome axis within a stem cell model of human aging


Dot1L is a barrier to histone acetylation during reprogramming to pluripotency. Coral K. Wille, Xiaoya Zhang, Spencer A. Haws, John M. Denu, Rupa Sridharan. Science Advances. 2023

Intrinsic catalytic properties of histone H3 lysine-9 methyltransferases preserve monomethylation levels under low S-adenosylmethionine. Spencer A. Haws*, Lillian J. Miller*, Diego Rojas La Luz, Vyacheslav I. Kuznetsov, Raymond C. Trievel, Gheorghe Craciun, and John M. Denu. JBC 2023. *These authors contributed equally.

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice. Pak HH, Haws SA, Green CL, Koller M, Lavarias MT, Richardson NE, Yang SE, Dumas SN, Sonsalla M, Bray L, Johnson M, Barnes S, Darley-Usmar V, Zhang J, Yen CE, Denu JM, Lamming DW. Nat Metab. 2021.

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence. Haws SA, Yu D, Ye C, Wille CK, Nguyen LC, Krautkramer KA, Tomasiewicz JL, Yang SE, Miller BR, Liu WH, Igarashi K, Sridharan R, Tu BP, Cryns VL, Lamming DW, Denu JM. Mol Cell 2020.

Metabolism and the Epigenome: A Dynamic Relationship. Haws SA, Leech CM and Denu JM. Trends Biochem Sci. 2020.

A practical guide for analysis of histone post-translational modification by mass spectrometry: Best practices and pitfalls. Thomas SP, Haws SA, Borth LE and Denu JM. Methods 2019.

PGC-1a Integrates a Metabolism and Growth Network Linked to Caloric Restriction. Miller KN, Clark JP, Martin SA, Howell PR, Burhans MS, Haws SA, Johnson NB, Rhoads TW, Pavelec DM, Eliceiri KW, Roopra AS, Ntambi JM, Denu JM, Parks BW, Anderson RM. Aging Cell 2019.

General method for rapid purification of native chromatin fragments. Kuznetsov VI, Haws SH, Fox CA, Denu JM. J Biol Chem 2018.