Spencer Haws

Credentials: Nutritional Sciences, NutriSci

Position title: Graduate Student

Email: shaws@wisc.edu


Ph.D., Molecular and Biochemical Nutrition, University of Wisconsin-Madison

B.S., Nutritional Sciences, University of Wisconsin-Madison

Research Description

Methyl-donor metabolism and the epigenome


Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice. Pak HH, Haws SA, Green CL, Koller M, Lavarias MT, Richardson NE, Yang SE, Dumas SN, Sonsalla M, Bray L, Johnson M, Barnes S, Darley-Usmar V, Zhang J, Yen CE, Denu JM, Lamming DW. Nat Metab. 2021.

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence. Haws SA, Yu D, Ye C, Wille CK, Nguyen LC, Krautkramer KA, Tomasiewicz JL, Yang SE, Miller BR, Liu WH, Igarashi K, Sridharan R, Tu BP, Cryns VL, Lamming DW, Denu JM. Mol Cell 2020.

Metabolism and the Epigenome: A Dynamic Relationship. Haws SA, Leech CM and Denu JM. Trends Biochem Sci. 2020.

A practical guide for analysis of histone post-translational modification by mass spectrometry: Best practices and pitfalls. Thomas SP, Haws SA, Borth LE and Denu JM. Methods 2019.

PGC-1a Integrates a Metabolism and Growth Network Linked to Caloric Restriction. Miller KN, Clark JP, Martin SA, Howell PR, Burhans MS, Haws SA, Johnson NB, Rhoads TW, Pavelec DM, Eliceiri KW, Roopra AS, Ntambi JM, Denu JM, Parks BW, Anderson RM. Aging Cell 2019.

General method for rapid purification of native chromatin fragments. Kuznetsov VI, Haws SH, Fox CA, Denu JM. J Biol Chem 2018.