Rush Dhillon

Education

• BSc. Environmental Biology, University of Alberta
• MSc. Watershed Ecosystems Graduate Studies, Trent University
• PhD. Biology, Queen’s University

Research Description

Rush’s research uses a comparative approach to examine the physiological and biochemical response of organisms to stressors. Specifically, Rush looks at aerobic and anaerobic pathways of metabolism in response to stress, and their implications for mitochondrial respiration. Currently, the focus of his research is to examine how acetylation and cellular redox status regulate mitochondrial metabolism and components of the electron transport system.

Affiliations

• Canadian Society of Zoologists

Selected Publications

SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction. Dhillon RS, Qin YA, van Ginkel PR, Fu VX, Vann JM, Lawton AJ, Green CL, Manchado-Gobatto FB, Gobatto CA, Lamming DW, Prolla TA, Denu JM. Aging Cell 2022.

Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at complex I in pancreatic β-cells. Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ. JBC 2019.

Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin. Krautkramer KA, Dhillon RS, Denu JM, Carey HV. Transl Res 2017.

Using comparative biology to understand how aging affects mitochondrial metabolism. Dhillon RS, Denu JM. Mol Cell Endocrinol 2017.

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity. Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ. Diabetes 2016