Alexis Lawton

Credentials: Biomolecular Chemistry

Position title: IPiB Graduate Student

Understanding the mechanisms and biological functions of reversible protein acetylation

Ph.D., Biomolecular Chemistry, University of Wisconsin-Madison

B.S., Biochemistry, University of Michigan – Ann Arbor

Molecular Biosciences Training Grant (MBTG) – Trainee

SIRT3 deficiency decreases oxidative metabolism capacity but increases lifespan in male mice under caloric restriction. Dhillon RS, Qin YA, van Ginkel PR, Fu VX, Vann JM, Lawton AJ, Green CL, Manchado-Gobatto FB, Gobatto CA, Lamming DW, Prolla TA, Denu JM. Aging Cell 2022.

Increased expression of SLC25A1/CIC causes an autistic-like phenotype with altered neuron morphology. Rigby MJ, Orefice NS, Lawton AJ, Ma M, Shapiro SL, Yi SY, Dieterich IA, Frelka A, Miles HN, Pearce RA, Yu JPJ, Li L, Denu JM, Puglielli L. Brain 2022.

SLC13A5/NaCT overexpression causes disrupted white matter integrity and an autistic-like phenotype. Rigby MJ, Orefice NS, Lawton AJ, Ma M, Shapiro SL, Yi WY, Dieterich IA, Frelka A, Miles HN, Pearce RA, Yu JPJ, Denu JM, Puglielli L. Brain Communications 2022.

Revealing Dynamic Protein Acetylation across Subcellular Compartments. Baeza J*, Lawton AJ*, Fan J, Smallegan MJ, Lienert I, Gandhi T, Bernhardt OM, Reiter L, Denu JM. J Proteome Res 2020. *Denotes co-first author

Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk. Dieterich IA, Lawton AJ, Peng Y, Yu Q, Rhoads, TW, Overmyer, KA, Cui Y, Armstrong EA, Howell PR, Burhans MS, Li L, Denu JM, Anderson RM, Puglielli L. Nat Commun 2019.