Position title: Graduate Student, IPiB
Ph.D., Biomolecular Chemistry, University of Wisconsin-Madison
B.S., Biochemistry, University of Illinois at Urbana-Champaign
Mechanisms of activating Sirtuin 6, a histone deacetylase important in epigenetic regulation.
Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6. Liu WH, Zheng J, Feldman JL, Klein MA, Kuznetsov VI, Peterson CL, Griffin PR, Denu JM. Nat Commun 2020.
Mechanism of Activation for the Sirtuin 6 Protein Deacylase. Klein MA, Lie C, Kuznetsov VI, Feltenberger JB, Tang W, Denu JM. J Biol Chem 2020.
Biological and Catalytic Functions of Sirtuin 6 as Targets for Small-Molecule Modulators. Klein MA and Denu JM. J Biol Chem. 2020.